BDBM294480 N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1- yl)phenyl)amino)-7H-pyrrolo[2,3-d]- pyrimidin-4-yl)oxy)phenyl)acrylamide::US9586965, Cpd 3

SMILES: CN1CCN(CC1)c2ccc(cc2F)Nc3nc4c(cc[nH]4)c(n3)Oc5cccc(c5)NC(=O)C=C

InChI Key: InChIKey=UOFYSRZSLXWIQB-UHFFFAOYSA-N

Data: 13 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 294480   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Human)	BDBM294480 (US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.399	n/a	n/a	n/a	n/a	7.5	25
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Tyrosine-protein kinase JAK3 (Human)	BDBM294480 (US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0911	n/a	n/a	n/a	n/a	7.5	25
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Tyrosine-protein kinase JAK2 (Human)	BDBM294480 (US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	501	n/a	n/a	n/a	n/a	7.5	25
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Tyrosine-protein kinase JAK1 (Human)	BDBM294480 (US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.27E+3	n/a	n/a	n/a	n/a	7.5	25
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Epidermal growth factor receptor (Human)	BDBM294480 (US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM294480 (US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM294480 (US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM294480 (US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM294480 (US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM294480 (US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM294480 (US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	279	n/a	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM294480 (US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM294480 (US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	177	n/a	n/a	n/a	n/a	n/a	n/a
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