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BDBM29471 Pyrazolo[1,5-a]-1,3,5-triazine, 12-40

SMILES: CCN(CC)c1nc(C)nc2c(c(C)nn12)-c1cc(OC)c(OC)cc1Br

InChI Key: InChIKey=UQOLDSLJSVLEGP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 29471   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29471
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-40)
Show SMILES CCN(CC)c1nc(C)nc2c(c(C)nn12)-c1cc(OC)c(OC)cc1Br
Show InChI InChI=1S/C19H24BrN5O2/c1-7-24(8-2)19-22-12(4)21-18-17(11(3)23-25(18)19)13-9-15(26-5)16(27-6)10-14(13)20/h9-10H,7-8H2,1-6H3
PDB
MMDB

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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 4.06n/an/an/an/an/a25



Bristol-Myers Squibb Co.



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair