BDBM296429 US10112942, Example 163::US10112942, Example 166::US10112942, Example 183::US10137124, Example 163::US10555944, Example 163::US10953005, Example 163::US12338253, Compound Selpercatinib(LOXO-292)::US20230322769, Compound Selpercatinib::US20240174674, Compound Selpercatinib

SMILES: COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC(C)(C)O)cn3ncc(C#N)c23)cn1

InChI Key: InChIKey=XIIOFHFUYBLOLW-UHFFFAOYSA-N

Data: 34 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 296429   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.09	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.17	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.07	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	172	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [G810R] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	43.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [G810R] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	43.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.98	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	24.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	24.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [G810R] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	531	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	29.3	n/a	n/a	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	84.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15.1	n/a	n/a	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [G810R] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	473	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [G810R] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	531	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	24.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,G810R] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	531	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	24.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [G810R] (Human)	BDBM296429 (US10112942, Example 163 | US10112942, Example 183 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	531	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair