BDBM296536 US10112942, Example 270::US10137124, Example 270::US10172851, Example 270::US10555944, Example 270::US10953005, Example 270

SMILES CCOc1cc(-c2ccc(nc2)N2CC3CC(C2)N3C(=O)c2ccc(OCCOC)nc2)c2c(cnn2c1)C#N

InChI Key InChIKey=CGHLSTDPQZMZEQ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 296536   

LigandPNGBDBM296536(US10112942, Example 270 | US10137124, Example 270 ...)
Affinity DataIC50: 272nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296536(US10112942, Example 270 | US10137124, Example 270 ...)
Affinity DataIC50: 272nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296536(US10112942, Example 270 | US10137124, Example 270 ...)
Affinity DataIC50: 272nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296536(US10112942, Example 270 | US10137124, Example 270 ...)
Affinity DataIC50: 272nMpH: 7.4Assay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

LigandPNGBDBM296536(US10112942, Example 270 | US10137124, Example 270 ...)
Affinity DataIC50: 272nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

LigandPNGBDBM296536(US10112942, Example 270 | US10137124, Example 270 ...)
Affinity DataIC50: 2.98E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

LigandPNGBDBM296536(US10112942, Example 270 | US10137124, Example 270 ...)
Affinity DataIC50: 2.98E+3nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

LigandPNGBDBM296536(US10112942, Example 270 | US10137124, Example 270 ...)
Affinity DataIC50: 2.98E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

LigandPNGBDBM296536(US10112942, Example 270 | US10137124, Example 270 ...)
Affinity DataIC50: 2.98E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

LigandPNGBDBM296536(US10112942, Example 270 | US10137124, Example 270 ...)
Affinity DataIC50: 2.98E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent