BDBM296608 6-(2-hydroxy-2- methylpropoxy)-4-(6- (6-((2-oxo-1,2- dihydropyridin-4- yl)methyl)-3,6- diazabicyclo[3.1.1] heptan-3-yl)pyridin-3- yl)pyrazolo[1,5- a]pyridine-3- carbonitrile::US10112942, Example 342::US10137124, Example 342::US10172851, Example 342::US10555944, Example 342::US10953005, Example 342

SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CC3CC(C2)N3Cc2cc[nH]c(=O)c2)c2c(cnn2c1)C#N

InChI Key InChIKey=ZWEMVOHBCKZBJU-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 296608   

LigandPNGBDBM296608(US10112942, Example 342 | 6-(2-hydroxy-2- methylpr...)
Affinity DataIC50: 63.8nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296608(US10112942, Example 342 | 6-(2-hydroxy-2- methylpr...)
Affinity DataIC50: 63.8nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296608(US10112942, Example 342 | 6-(2-hydroxy-2- methylpr...)
Affinity DataIC50: 63.8nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296608(US10112942, Example 342 | 6-(2-hydroxy-2- methylpr...)
Affinity DataIC50: 63.8nMpH: 7.4Assay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

LigandPNGBDBM296608(US10112942, Example 342 | 6-(2-hydroxy-2- methylpr...)
Affinity DataIC50: 63.8nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

LigandPNGBDBM296608(US10112942, Example 342 | 6-(2-hydroxy-2- methylpr...)
Affinity DataIC50: 310nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

LigandPNGBDBM296608(US10112942, Example 342 | 6-(2-hydroxy-2- methylpr...)
Affinity DataIC50: 310nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

LigandPNGBDBM296608(US10112942, Example 342 | 6-(2-hydroxy-2- methylpr...)
Affinity DataIC50: 310nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

LigandPNGBDBM296608(US10112942, Example 342 | 6-(2-hydroxy-2- methylpr...)
Affinity DataIC50: 310nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

LigandPNGBDBM296608(US10112942, Example 342 | 6-(2-hydroxy-2- methylpr...)
Affinity DataIC50: 310nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent