BDBM296657 6-(2-hydroxy- 2- methylpropoxy)- 4-(6-(6-(4- methylnico- tinoyl)-3,6- diazabicyclo[3. 1.1]heptan-3- yl)pyridin-3- yl)pyrazolo[1,5- a]pyridine-3- carbonitrile::US10112942, Example 391::US10137124, Example 391::US10172851, Example 391::US10555944, Example 391::US10953005, Example 391

SMILES Cc1ccncc1C(=O)N1C2CC1CN(C2)c1ccc(cn1)-c1cc(OCC(C)(C)O)cn2ncc(C#N)c12

InChI Key InChIKey=WGQDCYLDMKPOAD-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 296657   

LigandPNGBDBM296657(US10112942, Example 391 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 460nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296657(US10112942, Example 391 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 460nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

LigandPNGBDBM296657(US10112942, Example 391 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 460nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296657(US10112942, Example 391 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 460nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296657(US10112942, Example 391 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 460nMpH: 7.4Assay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

LigandPNGBDBM296657(US10112942, Example 391 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 5.37E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

LigandPNGBDBM296657(US10112942, Example 391 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 5.37E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

LigandPNGBDBM296657(US10112942, Example 391 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 5.37E+3nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

LigandPNGBDBM296657(US10112942, Example 391 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 5.37E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

LigandPNGBDBM296657(US10112942, Example 391 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 5.37E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent