BDBM296658 6-(2-hydroxy- 2- methylpropoxy)- 4-(6-(6- ((1r,4r)-4- hydroxycyclo- hexane-1- carbonyl)-3,6- diazabicyclo[3. 1.1]heptan-3- yl)pyridin-3- yl)pyrazolo[1,5- a]pyridine-3- carbonitrile::US10112942, Example 392::US10137124, Example 392::US10172851, Example 392::US10555944, Example 392::US10953005, Example 392

SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CC3CC(C2)N3C(=O)[C@H]2CC[C@H](O)CC2)c2c(cnn2c1)C#N

InChI Key InChIKey=SDBXOPPIMVIXSJ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 296658   

LigandPNGBDBM296658(US10112942, Example 392 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 171nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

LigandPNGBDBM296658(US10112942, Example 392 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 171nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296658(US10112942, Example 392 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 171nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296658(US10112942, Example 392 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 171nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296658(US10112942, Example 392 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 171nMpH: 7.4Assay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

LigandPNGBDBM296658(US10112942, Example 392 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 3.42E+3nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

LigandPNGBDBM296658(US10112942, Example 392 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 3.42E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent

LigandPNGBDBM296658(US10112942, Example 392 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 3.42E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

LigandPNGBDBM296658(US10112942, Example 392 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 3.42E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

LigandPNGBDBM296658(US10112942, Example 392 | 6-(2-hydroxy- 2- methylp...)
Affinity DataIC50: 3.42E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent