BDBM296869 US10111866, Example 2::US10292975, Example 2

SMILES: CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(OCCN(C)C)cc(c2)C(F)(F)F)c(F)c1

InChI Key: InChIKey=JCPFDKWEHMBUPR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 296869   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM296869 (US10111866, Example 2 | US10292975, Example 2) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(OCCN(C)C)cc(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C26H27F4N3O4/c1-4-36-23-14-24(34)31-15-21(23)16-5-6-17(22(27)9-16)10-25(35)32-19-11-18(26(28,29)30)12-20(13-19)37-8-7-33(2)3/h5-6,9,11-15H,4,7-8,10H2,1-3H3,(H,31,34)(H,32,35)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US10292975 (2019) BindingDB Entry DOI: 10.7270/Q2HT2RPC
					More data for this Ligand-Target Pair
RET Kinase (aa658-end) (Homo sapiens (Human))	BDBM296869 (US10111866, Example 2 | US10292975, Example 2) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(OCCN(C)C)cc(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C26H27F4N3O4/c1-4-36-23-14-24(34)31-15-21(23)16-5-6-17(22(27)9-16)10-25(35)32-19-11-18(26(28,29)30)12-20(13-19)37-8-7-33(2)3/h5-6,9,11-15H,4,7-8,10H2,1-3H3,(H,31,34)(H,32,35)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US10111866 (2018) BindingDB Entry DOI: 10.7270/Q2D220PR
					More data for this Ligand-Target Pair