BDBM29789 7,6,5 tricyclic sulfonamide, 35

SMILES CCN1c2cc(cc3c(CC)cn(CCS1(=O)=O)c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCOCC1

InChI Key InChIKey=VHIKANGIVZQCPI-XTEPFMGCSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 29789   

TargetBeta-secretase 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM29789(7,6,5 tricyclic sulfonamide, 35)
Affinity DataIC50:  5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Gsk

LigandPNGBDBM29789(7,6,5 tricyclic sulfonamide, 35)
Affinity DataIC50:  1.62E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM29789(7,6,5 tricyclic sulfonamide, 35)
Affinity DataIC50:  150nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed