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BDBM29835 spiro-carboxamide scaffold, 8

SMILES: Fc1ccc(CC(=O)N2CCC3(C2)CCCCC3)cc1

InChI Key: InChIKey=DUGMOKILUJGTPV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 29835   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM29835
PNG
(spiro-carboxamide scaffold, 8)
Show SMILES Fc1ccc(CC(=O)N2CCC3(C2)CCCCC3)cc1
Show InChI InChI=1S/C17H22FNO/c18-15-6-4-14(5-7-15)12-16(20)19-11-10-17(13-19)8-2-1-3-9-17/h4-7H,1-3,8-13H2
PDB
MMDB

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Similars

Article
PubMed
n/an/a 1.41E+3n/an/an/an/a7.437



Merck Serono



Assay Description
11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...


Bioorg Med Chem Lett 19: 3682-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.123
BindingDB Entry DOI: 10.7270/Q2X065DQ
More data for this
Ligand-Target Pair