BDBM29881 alkynyl ether, 23

SMILES OCC#CCOc1cc(COc2ccc(cc2)C(F)(F)F)ccc1Sc1ccc(OCC(O)=O)c2CCCCc12

InChI Key InChIKey=LSQBHBUVOUMWSA-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 29881   

TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Amgen

LigandPNGBDBM29881(alkynyl ether, 23)
Affinity DataKi:  2nM EC50:  220nMAssay Description:The human PPARdelta ligand binding was directly measured using a scintillation proximity assay. Plates were read on a Packard TopCount. IC50 values f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Amgen

LigandPNGBDBM29881(alkynyl ether, 23)
Affinity DataKi:  210nM EC50:  5.90E+3nMAssay Description:The human PPARgamma ligand binding was directly measured using a filtration assay in a UniFilter 350 96-well assay plate (Polyfiltronics). The reacti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Amgen

LigandPNGBDBM29881(alkynyl ether, 23)
Affinity DataKi:  1.70E+3nM ΔG°:  -7.79kcal/mole EC50: >1.00E+5nMpH: 7.1 T: 2°CAssay Description:The human PPARalpha ligand binding was directly measured using a scintillation proximity assay. Plates were read on a Packard TopCount. IC50 values f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed