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BDBM299365 6-(3-chloro-5- fluoro-phenyl) quinazolin-4- amine::US9592235, Example 171::US9855269, Compound 15

SMILES: Nc1ncnc2ccc(cc12)-c1cc(F)cc(Cl)c1

InChI Key: InChIKey=QWGJBVJDHIRFFJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299365   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299365
PNG
(6-(3-chloro-5- fluoro-phenyl) quinazolin-4- amine ...)
Show SMILES Nc1ncnc2ccc(cc12)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C14H9ClFN3/c15-10-3-9(4-11(16)6-10)8-1-2-13-12(5-8)14(17)19-7-18-13/h1-7H,(H2,17,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 226n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...


US Patent US9855269 (2018)


BindingDB Entry DOI: 10.7270/Q2VH5R4B
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299365
PNG
(6-(3-chloro-5- fluoro-phenyl) quinazolin-4- amine ...)
Show SMILES Nc1ncnc2ccc(cc12)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C14H9ClFN3/c15-10-3-9(4-11(16)6-10)8-1-2-13-12(5-8)14(17)19-7-18-13/h1-7H,(H2,17,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 226n/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...


US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair