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BDBM299923 (1R,2S)-2-[({4- [(3,3- difluoroazetidin-1- yl)carbonyl]-6-[4- (1H-pyrazolo[3,4- b]pyridin-3- yl)piperidin-1-yl]- 1,3,5-triazin-2- yl}oxy) methyl]cyclo- propanecarbonitrile::US9593097, Example 293

SMILES: FC1(F)CN(C1)C(=O)c1nc(OC[C@H]2C[C@H]2C#N)nc(n1)N1CCC(CC1)c1n[nH]c2ncccc12

InChI Key: InChIKey=LEBMWPYWFGPBIX-PVRQQBJHNA-N

Data: 1 KI

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299923   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299923
PNG
((1R,2S)-2-[({4- [(3,3- difluoroazetidin-1- yl)carb...)
Show SMILES FC1(F)CN(C1)C(=O)c1nc(OC[C@H]2C[C@H]2C#N)nc(n1)N1CCC(CC1)c1n[nH]c2ncccc12
Show InChI InChI=1/C23H23F2N9O2/c24-23(25)11-34(12-23)20(35)19-28-21(30-22(29-19)36-10-15-8-14(15)9-26)33-6-3-13(4-7-33)17-16-2-1-5-27-18(16)32-31-17/h1-2,5,13-15H,3-4,6-8,10-12H2,(H,27,31,32)/t14-,15+/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
17.6n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...


US Patent US9593097 (2017)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair