BDBM300426 US10130622, Example 00005
SMILES COCCS(=O)(=O)NC(=O)c1cc(N2CCC(COC)CC2)c2c(nn(-c3ccc(F)cc3)c2n1)C(C)C
InChI Key InChIKey=DPGMCWVUTKWPOQ-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 300426
TargetCystic fibrosis transmembrane conductance regulator [G550E](Homo sapiens (Human))
Abbvie S.á.R.L.
US Patent
Abbvie S.á.R.L.
US Patent
Affinity DataIC50: 102nMAssay Description:YFP-Halide Influx Assay for the CFTR-ΔF508 Mutation and Suppressor mutants (I539T or G550E)The YFP halide influx assay measures the functionalit...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Abbvie S.á.R.L.
US Patent
Abbvie S.á.R.L.
US Patent
Affinity DataIC50: 103nMAssay Description:For this purpose, HEK293 cells are transfected with plasmid DNA containing WT CFTR and seeded in 96 well plates (70,000 HEK cells/well). Two days aft...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Abbvie S.á.R.L.
US Patent
Abbvie S.á.R.L.
US Patent
Affinity DataIC50: 40nMAssay Description:For this purpose, HEK293 cells are transfected with plasmid DNA containing WT CFTR and seeded in 96 well plates (70,000 HEK cells/well). Two days aft...More data for this Ligand-Target Pair