BDBM301310 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one::US10131667, Example 126::US11053246, Example 126::US11407750, Compound 6::US9611267, Example 126

SMILES CCN1C(=O)N(c2c(F)c(OC)cc(OC)c2F)Cc2cnc3[nH]c(CN4CCOCC4)cc3c21

InChI Key InChIKey=HCDMJFOHIXMBOV-UHFFFAOYSA-N

Data  71 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 71 hits for monomerid = 301310   

TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human recombinant FGFR3 by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of wild type FGFR2 (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant FGFR1 by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of N-terminal GST tagged recombinant human FGFR2 (400 to 821 residues) expressed in an Sf9 infected baculovirus expression system using bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1/2/3/4(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.3 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.3 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant FGFR2 by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human Nav1.3 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild-type FGFR2 (unknown origin) by radiometric kinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of FGFR2 E565G mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human FGFR1 using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.960nMAssay Description:Inhibition of wild type FGFR3 (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.970nMAssay Description:Inhibition of wild-type FGFR3 (unknown origin) by radiometric kinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human Nav1.3 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of N-terminal His-Avi tagged recombinant human FGFR3 (447 to 761 residues) expressed in an Sf9 infected baculovirus expression system usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of wild-type FGFR1 (unknown origin) by radiometric kinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of FGFR3 K650E mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of FGFR2 K641R mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 3nMAssay Description:Inhibition of FGFR2 V564I mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of FGFR2 N549H mutant (unknown origin) by radiometric kinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of FGFR3 K650M mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of FGFR3 K650E mutant (unknown origin) by radiometric kinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Mouse)
Incyte

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 22nMAssay Description:In vivo inhibition of FGFR2 in po dosed SCID mouse xenografted with human KATO III stomach cancer cell line administered as single dose and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human FGFR4 (460 to 802 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant FGFR4 by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 30nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 30nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 30nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 35nMAssay Description:Inhibition of wild-type FGFR4 (unknown origin) by radiometric kinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 65nMAssay Description:Inhibition of FGFR3 V555L mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 70nMAssay Description:Inhibition of FGFR2 V564F mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
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