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BDBM303723 4-[[[5-[2-(4- chlorophenyl)ethyl]- 1,3,4-thiadiazol-2- yl]amino]methyl]-1-[4- (morpholinomethyl) phenyl]pyrrolidin-2-one::US10138230, Example F153

SMILES: Clc1ccc(CCc2nnc(NCC3CN(C(=O)C3)c3ccc(CN4CCOCC4)cc3)s2)cc1

InChI Key: InChIKey=YVBHUXITHOVNJB-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 303723   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM303723
PNG
(4-[[[5-[2-(4- chlorophenyl)ethyl]- 1,3,4-thiadiazo...)
Show SMILES Clc1ccc(CCc2nnc(NCC3CN(C(=O)C3)c3ccc(CN4CCOCC4)cc3)s2)cc1
Show InChI InChI=1/C26H30ClN5O2S/c27-22-6-1-19(2-7-22)5-10-24-29-30-26(35-24)28-16-21-15-25(33)32(18-21)23-8-3-20(4-9-23)17-31-11-13-34-14-12-31/h1-4,6-9,21H,5,10-18H2,(H,28,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
Measuring ATX activity using an enzyme coupled Quanta Red assay (Thermo Scientific Pierce Protein Research Products, Product #15159) was determined a...


US Patent US10138230 (2018)


Article DOI: 10.1021/jm040063i
BindingDB Entry DOI: 10.7270/Q27S7QV8
More data for this
Ligand-Target Pair