BDBM3053 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 20::6-(2,6-Dichlorophenyl)-2-hydroxy-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one::6-(2,6-dichlorophenyl)-2-hydroxy-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one::PD 166285 analog

SMILES Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2c[nH]c(=O)nc21

InChI Key InChIKey=DYPDXKXBFNUDPU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 3053   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

LigandChemical structure of BindingDB Monomer ID 3053BDBM3053(6-(2,6-dichlorophenyl)-2-hydroxy-8-methyl-7H,8H-py...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Parke-Davis Pharmaceutical Research

LigandChemical structure of BindingDB Monomer ID 3053BDBM3053(6-(2,6-dichlorophenyl)-2-hydroxy-8-methyl-7H,8H-py...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandChemical structure of BindingDB Monomer ID 3053BDBM3053(6-(2,6-dichlorophenyl)-2-hydroxy-8-methyl-7H,8H-py...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed