BDBM305821 (1r,3r)-3-(Cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile::US10144738, Example 20::US10822341, Example 20::US11472809, Example 20

SMILES: Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)[C@@]1(CC#N)C[C@@H](C1)C#N

InChI Key: InChIKey=XPLZTJWZDBFWDE-UHFFFAOYSA-N

Data: 40 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 40 hits for monomerid = 305821   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1/Tyrosine-protein kinase JAK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	566	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	383	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	148	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	427	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1/Tyrosine-protein kinase JAK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	201	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1/Tyrosine-protein kinase JAK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
JAK3/JAK1 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
JAK3/JAK1 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
JAK3/JAK1 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1/JAK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	383	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	383	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	383	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	383	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	383	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	383	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM305821 (US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair