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BDBM305909 US10144742, Compound I-71

SMILES: O=C(NCCc1ncc[nH]1)c1ccc2nc(N3CCC(CC3)N3CCOCC3)c(nc2c1)-c1ccccc1

InChI Key: InChIKey=ONWMOHQXQRRVNK-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 305909   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM305909
PNG
(US10144742, Compound I-71)
Show SMILES O=C(NCCc1ncc[nH]1)c1ccc2nc(N3CCC(CC3)N3CCOCC3)c(nc2c1)-c1ccccc1
Show InChI InChI=1S/C29H33N7O2/c37-29(32-11-8-26-30-12-13-31-26)22-6-7-24-25(20-22)33-27(21-4-2-1-3-5-21)28(34-24)36-14-9-23(10-15-36)35-16-18-38-19-17-35/h1-7,12-13,20,23H,8-11,14-19H2,(H,30,31)(H,32,37)
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PC cid
PC sid
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Article
US Patent
n/an/a 300n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)


Article DOI: 10.1016/j.bmcl.2005.10.088
BindingDB Entry DOI: 10.7270/Q2NV9M91
More data for this
Ligand-Target Pair