BDBM3068 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 35::6-(2,6-dichlorophenyl)-8-methyl-2-[(pyridin-3-ylmethyl)amino]-7H,8H-pyrido[2,3-d]pyrimidin-7-one::PD 166285 analog

SMILES Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(NCc3cccnc3)nc21

InChI Key InChIKey=XHGSDPKRXJOFGF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 3068   

TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandChemical structure of BindingDB Monomer ID 3068BDBM3068(6-(2,6-dichlorophenyl)-8-methyl-2-[(pyridin-3-ylme...)
Affinity DataIC50: 3.15E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

LigandChemical structure of BindingDB Monomer ID 3068BDBM3068(6-(2,6-dichlorophenyl)-8-methyl-2-[(pyridin-3-ylme...)
Affinity DataIC50: 3.20E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandChemical structure of BindingDB Monomer ID 3068BDBM3068(6-(2,6-dichlorophenyl)-8-methyl-2-[(pyridin-3-ylme...)
Affinity DataIC50: 5.00E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Parke-Davis Pharmaceutical Research

LigandChemical structure of BindingDB Monomer ID 3068BDBM3068(6-(2,6-dichlorophenyl)-8-methyl-2-[(pyridin-3-ylme...)
Affinity DataIC50: 6.60E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed