BDBM3085 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one::PD 166285 analog::PD166326

SMILES: CN1c2c(cnc(n2)Nc3cccc(c3)CO)C=C(C1=O)c4c(cccc4Cl)Cl

InChI Key: InChIKey=ZIQFYVPVJZEOFS-UHFFFAOYSA-N

Data: 14 IC50

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 3085   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 1 (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.68	n/a	n/a	n/a	n/a	7.5	25
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Fibroblast growth factor receptor 1 (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	61.5	n/a	n/a	n/a	n/a	7.4	25
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Platelet-derived growth factor receptor beta (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	139	n/a	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase Lck (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	636	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM3085 (6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
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