BDBM310359 (3R,5S)—N-(4-(4,6-dimethoxy-5-pyrimidinyl)-5-((2R)-1,4-dioxan-2-yl)-4H-1,2,4-triazol-3-yl)-1-(5-fluoro-2-pyrimidinyl)-5-(1-methylethoxy)-3-piperidinesulfonamide or (3R,5S)—N-(4-(4,6-dimethoxy-5-pyrimidinyl)-5-((2S)-1,4-dioxan-2-yl)-4H-1,2,4-triazol-3-yl)-1-(5-fluoro-2-pyrimidinyl)-5-(1-methylethoxy)-3-piperidinesulfonamide::US10150760, Example 179.0::US10150760, Example 180.0

SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H]2C[C@@H](CN(C2)c2ncc(F)cn2)OC(C)C)nnc1[C@@H]1COCCO1

InChI Key InChIKey=FJJPEMOTKSRQSO-KSZLIROESA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 310359   

TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM310359((3R,5S)—N-(4-(4,6-dimethoxy-5-pyrimidinyl)-5-...)
Affinity DataEC50:  240nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApelin receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM310359((3R,5S)—N-(4-(4,6-dimethoxy-5-pyrimidinyl)-5-...)
Affinity DataEC50:  710nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent