BindingDB PrimarySearch

BDBM31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972

SMILES: CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1

InChI Key: InChIKey=ODPGGGTTYSGTGO-UHFFFAOYSA-N

Data: 10 KI 10 IC50 916 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 936 hits for monomerid = 31085
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.30	n/a	n/a	n/a	7.4	25
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ALK tyrosine kinase receptor (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	7.4	25
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Aurora kinase C (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	740	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase receptor UFO (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 11B (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 11A (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 19 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.5	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 7 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.5	n/a	n/a	n/a	7.4	23
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Cyclin-dependent kinase 8 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.40	n/a	n/a	n/a	7.4	23
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Cyclin-dependent kinase 9 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	190	n/a	n/a	n/a	7.4	23
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Dual specificity protein kinase CLK1 [R432A] (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	110	n/a	n/a	n/a	7.4	23
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Dual specificity protein kinase CLK4 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	290	n/a	n/a	n/a	7.4	23
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	5.80	n/a	n/a	n/a	7.4	25
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0.690	n/a	n/a	n/a	7.4	25
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Discoidin domain-containing receptor 2 [A642S] (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	11	n/a	n/a	n/a	7.4	25
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Epidermal growth factor receptor [G719C] (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	220	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 3 [1-975] (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	80	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	380	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	7.4	25
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Mitogen-activated protein kinase 15 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	94	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 1 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	86	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0.790	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.90	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	11	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	11	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.30	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 3 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	120	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase FRK (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	26	n/a	n/a	n/a	7.4	25
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P2Y purinoceptor 14 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	7.4	25
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Mitogen-activated protein kinase 9 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	56	n/a	n/a	n/a	7.4	25
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Mitogen-activated protein kinase kinase kinase kinase 1 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 3 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 5 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Mer (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a
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Hepatocyte growth factor receptor (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a
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MAP kinase-interacting serine/threonine-protein kinase 1 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a
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MAP kinase-interacting serine/threonine-protein kinase 2 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 3 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a
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Muscle, skeletal receptor tyrosine-protein kinase (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	8.10	n/a	n/a	n/a	n/a	n/a
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cAMP-dependent protein kinase catalytic subunit alpha (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a
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Receptor-interacting serine/threonine-protein kinase 1 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-4 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-5 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a
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STE20-like serine/threonine-protein kinase (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 33 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase receptor Tie-1 (Human)	BDBM31085 (cid_11409972 \| 1-[4-[(4-ethylpiperazin-1-yl)methyl...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a
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