BDBM13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10

SMILES: Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C

InChI Key: InChIKey=MVCOAUNKQVWQHZ-UHFFFAOYSA-N

Data: 7 KI  235 IC50  891 Kd  1 EC50  1 K_off  1 K_on

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1136 hits for monomerid = 13533   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 [201-500] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,Q252H] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,Y253F] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,E255K] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,M351T] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,F359V] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,H396P] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,T315I] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,T315N] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit [N822K] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mast/stem cell growth factor receptor Kit [V559D] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mast/stem cell growth factor receptor Kit [V559D,T670I] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase 14 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.100	n/a	n/a	n/a	7.0	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.100	n/a	n/a	n/a	7.0	23
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Mitogen-activated protein kinase 14 (Mouse)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.0460	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	42	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 19 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	200	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Cyclin-dependent kinase 8 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	220	n/a	n/a	n/a	7.4	23
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	8.10E+3	n/a	n/a	n/a	7.4	25
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.90	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Discoidin domain-containing receptor 2 [A642S] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	33	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Epidermal growth factor receptor [G719C] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.00E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 3 [1-975] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	880	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Ephrin type-A receptor 7 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 7 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	860	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Mitogen-activated protein kinase 15 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.00E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Vascular endothelial growth factor receptor 3 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.10E+3	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase FRK (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	7.4	25
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Mitogen-activated protein kinase 9 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.30	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Tyrosine-protein kinase Mer (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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MAP kinase-interacting serine/threonine-protein kinase 2 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
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Muscle, skeletal receptor tyrosine-protein kinase (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a
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STE20-like serine/threonine-protein kinase (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase receptor Tie-1 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a
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Angiopoietin-1 receptor (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
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BDNF/NT-3 growth factors receptor (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a
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NT-3 growth factor receptor (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a
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Citron Rho-interacting kinase (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM13533 (1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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