BindingDB PrimarySearch

BDBM31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518

SMILES: Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12

InChI Key: InChIKey=YABJJWZLRMPFSI-UHFFFAOYSA-N

Data: 6 KI 20 IC50 807 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 833 hits for monomerid = 31088
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 19 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	5.10E+3	n/a	n/a	n/a	7.4	25
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	250	n/a	n/a	n/a	7.4	25
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	13	n/a	n/a	n/a	7.4	25
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Discoidin domain-containing receptor 2 [A642S] (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	960	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 1 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	800	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 3 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase FRK (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	590	n/a	n/a	n/a	7.4	25
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Mitogen-activated protein kinase kinase kinase kinase 5 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a
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STE20-like serine/threonine-protein kinase (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase receptor Tie-1 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a
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Angiopoietin-1 receptor (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a
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Citron Rho-interacting kinase (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 1 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lyn (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 6 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a
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RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase TNNI3K (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 20 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [1-999,Q252H] (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	5.80E+5	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL2 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a
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5'-AMP-activated protein kinase catalytic subunit alpha-1 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 2 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 8 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase HCK (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 4 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase Nek5 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a
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Interferon-induced, double-stranded RNA-activated protein kinase (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	950	n/a	n/a	n/a	n/a	n/a
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Receptor-interacting serine/threonine-protein kinase 2 (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	950	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a
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TRAF2 and NCK-interacting protein kinase (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a
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Pirin (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
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RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM31088 (1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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