BDBM31090 (E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide::EKB-569::Pelitinib::cid_6445562

SMILES: CCOc1cc2c(cc1NC(=O)/C=C/CN(C)C)c(c(cn2)C#N)Nc3ccc(c(c3)Cl)F

InChI Key: InChIKey=WVUNYSQLFKLYNI-UHFFFAOYSA-N

Data: 3 KI  26 IC50  490 Kd  1 EC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 535 hits for monomerid = 31090   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	860	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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ALK tyrosine kinase receptor (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.10E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1 [R432A] (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	7.4	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK4 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.90E+3	n/a	n/a	n/a	7.4	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.30E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [G719C] (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.240	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 3 [1-975] (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.00E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase FRK (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	680	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 3 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 5 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
STE20-like serine/threonine-protein kinase (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 33 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor Tie-1 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase 32B (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Blk (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Citron Rho-interacting kinase (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.230	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fgr (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	950	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Fyn (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Lyn (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase TNNI3K (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase kinase kinase 20 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.30E+5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL2 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Calcium/calmodulin-dependent protein kinase kinase 1 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase kinase 2 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK2 (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase CSK (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Casein kinase I isoform delta (Human)	BDBM31090 ((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair