BDBM31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649

SMILES: OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1

InChI Key: InChIKey=HHFBDROWDBDFBR-UHFFFAOYSA-N

Data: 1 KI  36 IC50  821 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 866 hits for monomerid = 31093   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	450	n/a	n/a	n/a	7.4	25
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Aurora kinase A (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.5	n/a	n/a	n/a	7.4	25
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Aurora kinase B (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a
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Aurora kinase C (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	26	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase receptor UFO (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.20E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 3 [1-975] (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	580	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-B receptor 3 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.50E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-B receptor 4 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	560	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 1 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 3 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	7.4	25
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Aurora kinase A (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	22
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Aurora kinase B (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.30	n/a	n/a	n/a	n/a	7.5	22
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Aurora kinase A (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	30
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Tyrosine-protein kinase Mer (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase receptor Tie-1 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
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Angiopoietin-1 receptor (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 1 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fgr (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lyn (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase ABL1 [1-999,Q252H] (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.40E+5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL2 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a
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Dual specificity protein kinase CLK2 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase CSK (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor [1-999,L858R] (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.20E+6	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 2 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 4 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 5 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
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Ephrin type-B receptor 1 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fer (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 2 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase HCK (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 2-beta (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase ROS (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase SIK1 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a
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Non-receptor tyrosine-protein kinase TNK1 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Yes (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK4 (Human)	BDBM31093 (cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a
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