BDBM24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893

SMILES: CC1(CNc2c1ccc(c2)NC(=O)c3cccnc3NCc4ccncc4)C

InChI Key: InChIKey=RAHBGWKEPAQNFF-UHFFFAOYSA-N

Data: 7 KI  22 IC50  799 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 828 hits for monomerid = 24773   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 1 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
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Vascular endothelial growth factor receptor 2 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	22
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Vascular endothelial growth factor receptor 2 (Mouse)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	22
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Vascular endothelial growth factor receptor 3 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
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Fibroblast growth factor receptor 1 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.80E+3	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
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Mast/stem cell growth factor receptor Kit (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	22
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Platelet-derived growth factor receptor beta (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	84	n/a	n/a	n/a	n/a	7.5	22
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
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Epidermal growth factor receptor (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	7.5	22
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	7.5	22
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Mitogen-activated protein kinase 14 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase C (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	7.4	25
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.60	n/a	n/a	n/a	7.4	25
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	260	n/a	n/a	n/a	7.4	25
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Epidermal growth factor receptor [G719C] (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	490	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Vascular endothelial growth factor receptor 1 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	12	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	71	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.50E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Vascular endothelial growth factor receptor 3 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	9.70	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Tyrosine-protein kinase FRK (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	99	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Platelet-derived growth factor receptor alpha (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Platelet-derived growth factor receptor beta (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a
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STE20-like serine/threonine-protein kinase (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Vascular endothelial growth factor receptor 2 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a
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Citron Rho-interacting kinase (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Epidermal growth factor receptor (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Epidermal growth factor receptor (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 1 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 4 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fgr (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.90E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lyn (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 6 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
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RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase TNNI3K (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM24773 (N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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