BDBM13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522

SMILES: COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1

InChI Key: InChIKey=UXXQOJXBIDBUAC-UHFFFAOYSA-N

Data: 5 KI  33 IC50  1172 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1210 hits for monomerid = 13535   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 [201-500] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [201-500,Q252H] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,Y253F] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,E255K] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,M351T] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,F359V] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [201-500,H396P] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,T315I] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,T315N] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit [N822K] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit [V559D] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [V559D,T670I] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
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Aurora kinase C (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	7.4	25
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Dual specificity protein kinase CLK1 [R432A] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	630	n/a	n/a	n/a	7.4	23
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Dual specificity protein kinase CLK4 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	7.4	23
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.90	n/a	n/a	n/a	7.4	25
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Epidermal growth factor receptor [G719C] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	210	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 1 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	310	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	9.10	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	29	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Mitogen-activated protein kinase kinase kinase kinase 5 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Platelet-derived growth factor receptor alpha (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Platelet-derived growth factor receptor beta (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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High affinity nerve growth factor receptor (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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BDNF/NT-3 growth factors receptor (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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NT-3 growth factor receptor (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [1-999,L858R] (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.00E+5	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 16 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 3 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.30E+5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 1/2/3/4 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Human)	BDBM13535 (N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair