BDBM311834 8-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-7-isopropyl-imidazo[1,2-c]pyrimidine::US10155769, Example 72

SMILES CC(C)c1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)F

InChI Key InChIKey=YZZCVOQEIYHQSP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311834   

TargetVoltage-dependent calcium channel gamma-2 subunit(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM311834(8-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-7-...)
Affinity DataIC50:  0.316nMAssay Description:An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent