BDBM31197 CHEMBL211045::Nutlin-3::med.21724, Compound 186

SMILES: COc1ccc(C2=NC(C(N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1

InChI Key: InChIKey=BDUHCSBCVGXTJM-UHFFFAOYSA-N

Data: 4 KI  4 IC50  2 Kd  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 31197   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orf1a protein (MERS-CoV)	BDBM31197 (CHEMBL211045 | Nutlin-3 | med.21724, Compound 186) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.69E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
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E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM31197 (CHEMBL211045 | Nutlin-3 | med.21724, Compound 186) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
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Protein Mdm4 (Human)	BDBM31197 (CHEMBL211045 | Nutlin-3 | med.21724, Compound 186) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM31197 (CHEMBL211045 | Nutlin-3 | med.21724, Compound 186) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM31197 (CHEMBL211045 | Nutlin-3 | med.21724, Compound 186) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	263	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM31197 (CHEMBL211045 | Nutlin-3 | med.21724, Compound 186) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM31197 (CHEMBL211045 | Nutlin-3 | med.21724, Compound 186) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM31197 (CHEMBL211045 | Nutlin-3 | med.21724, Compound 186) Show SMILES Show InChI	GoogleScholar	UniChem		30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM31197 (CHEMBL211045 | Nutlin-3 | med.21724, Compound 186) Show SMILES Show InChI	GoogleScholar	UniChem		36	-10.1	n/a	n/a	n/a	n/a	n/a	7.5	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM31197 (CHEMBL211045 | Nutlin-3 | med.21724, Compound 186) Show SMILES Show InChI	GoogleScholar	UniChem		36	-10.1	n/a	n/a	n/a	n/a	n/a	7.5	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM31197 (CHEMBL211045 | Nutlin-3 | med.21724, Compound 186) Show SMILES Show InChI	GoogleScholar	UniChem		280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair