BDBM313262 US10166249, Example 496

SMILES Cn1nc(OC[C@@H]2CCc3cc(ccc3C2)[C@H]2CC[C@](N)(COP(O)(O)=O)C2)cc1C(F)(F)F

InChI Key InChIKey=NJLWSJQLXABVDA-YMTYPPQLSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 313262   

TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313262(US10166249, Example 496)
Affinity DataIC50: <10nMAssay Description:Membranes were prepared from CHO cells expressing human S1P1. Cells pellets (1×109 cells/pellet) were suspended in buffer containing 20 mM HEPES (4-(...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313262(US10166249, Example 496)
Affinity DataEC50: >625nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 l/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313262(US10166249, Example 496)
Affinity DataEC50: <10nMAssay Description:hS1P1/CHO cells were plated into BD Amine 384-well plates the day before the assay. On the day of the assay, growth medium was removed and replaced w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313262(US10166249, Example 496)
Affinity DataEC50: <10nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 l/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent