BDBM313325 2-(2-cyanopropan-2-yl)- N-(3-(5-(3- formyloxetan-3-yl)-6- methoxypyridin-3-yl)-4- methylphenyl)isonicotin- amide::US10167279, Example 43

SMILES COc1ncc(cc1C1(COC1)C=O)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)ccc1C

InChI Key InChIKey=LZLXCWZZYYKQQM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 313325   

TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM313325(2-(2-cyanopropan-2-yl)- N-(3-(5-(3- formyloxetan-3...)
Affinity DataIC50:  1.02E+4nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM313325(2-(2-cyanopropan-2-yl)- N-(3-(5-(3- formyloxetan-3...)
Affinity DataIC50:  2.67E+3nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent