BDBM313326 N-(5'-(3-fluorooxetan-3- yl)-1'-(3- hydroxypropyl)-2- methyl-6'-oxo-1',6'- dihydro-[3,3'-bipyridin]- 5-yl)-3- (trifluoromethyl)benzamide::US10167279, Example 44

SMILES Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(c(=O)n(CCCO)c1)C1(F)COC1

InChI Key InChIKey=FRKSLJSPQVGZID-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 313326   

TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM313326(N-(5'-(3-fluorooxetan-3- yl)-1'-(3- hydroxypropyl)...)
Affinity DataIC50:  6.79E+4nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM313326(N-(5'-(3-fluorooxetan-3- yl)-1'-(3- hydroxypropyl)...)
Affinity DataIC50:  8.63E+3nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent