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BDBM313429 US10167270, Example 120

SMILES: CN(CCCCc1ccccc1)c1nc(nc2ccccc12)-c1cccnc1

InChI Key: InChIKey=IJCHLSOUODSNEP-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 313429   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysosomal acid glucosylceramidase


(Homo sapiens (Human))
BDBM313429
PNG
(US10167270, Example 120)
Show SMILES CN(CCCCc1ccccc1)c1nc(nc2ccccc12)-c1cccnc1
Show InChI InChI=1S/C24H24N4/c1-28(17-8-7-12-19-10-3-2-4-11-19)24-21-14-5-6-15-22(21)26-23(27-24)20-13-9-16-25-18-20/h2-6,9-11,13-16,18H,7-8,12,17H2,1H3
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MMDB

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PC cid
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US Patent
n/an/a 3.16E+3n/an/an/an/an/an/a



Northwestern University

US Patent


Assay Description
The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...


US Patent US10167270 (2019)


BindingDB Entry DOI: 10.7270/Q2862JH8
More data for this
Ligand-Target Pair