BDBM313487 2-(2-cyanopropan-2-yl)- N-(3-(5-(3- (fluoromethyl)oxetan-3- yl)-6-methoxypyridin-3- yl)-4- methylphenyl)isonicotin- amide::US10167279, Example 106

SMILES COc1ncc(cc1C1(CF)COC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)ccc1C

InChI Key InChIKey=NRJWTGFPQAYOOI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 313487   

TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM313487(2-(2-cyanopropan-2-yl)- N-(3-(5-(3- (fluoromethyl)...)
Affinity DataIC50:  580nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM313487(2-(2-cyanopropan-2-yl)- N-(3-(5-(3- (fluoromethyl)...)
Affinity DataIC50:  146nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent