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BDBM313539 N-(6'-ethoxy-2-methyl- 5'-(tetrahydro-2H-pyran- 4-yl)-[3,3'-bipyridin]-5- yl)-6-(trifluoromethyl) pyridazine-4-carboxamide::US10167279, Example 163

SMILES: CCOc1ncc(cc1C1CCOCC1)-c1cc(NC(=O)c2cnnc(c2)C(F)(F)F)cnc1C

InChI Key: InChIKey=XPLCJCINVSLPKA-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 313539   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM313539
PNG
(N-(6'-ethoxy-2-methyl- 5'-(tetrahydro-2H-pyran- 4-...)
Show SMILES CCOc1ncc(cc1C1CCOCC1)-c1cc(NC(=O)c2cnnc(c2)C(F)(F)F)cnc1C
Show InChI InChI=1S/C24H24F3N5O3/c1-3-35-23-20(15-4-6-34-7-5-15)8-16(11-29-23)19-10-18(13-28-14(19)2)31-22(33)17-9-21(24(25,26)27)32-30-12-17/h8-13,15H,3-7H2,1-2H3,(H,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...


US Patent US10167279 (2019)


BindingDB Entry DOI: 10.7270/Q2W0981V
More data for this
Ligand-Target Pair