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BDBM31450 phenylaminoethyl guanidine deriv., 22da

SMILES: NC(=N)NCCNc1ccc(cc1-c1ccc(cc1)C#N)C(=O)Nc1ccc(cc1)N(Cc1ccccc1)Cc1ccccc1

InChI Key: InChIKey=UATBQCTVVMMYJI-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 31450   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM31450
PNG
(phenylaminoethyl guanidine deriv., 22da)
Show SMILES NC(=N)NCCNc1ccc(cc1-c1ccc(cc1)C#N)C(=O)Nc1ccc(cc1)N(Cc1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C37H35N7O/c38-24-27-11-13-30(14-12-27)34-23-31(15-20-35(34)41-21-22-42-37(39)40)36(45)43-32-16-18-33(19-17-32)44(25-28-7-3-1-4-8-28)26-29-9-5-2-6-10-29/h1-20,23,41H,21-22,25-26H2,(H,43,45)(H4,39,40,42)
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Similars

Article
PubMed
n/an/a 7.80E+4n/an/an/an/an/a25



Yale University



Assay Description
A bead-based FP assay methodology, termed IMAP, has been developed for the serine/threonine kinase, AKT that allows for direct measurement of product...


Bioorg Med Chem 17: 1764-71 (2009)


Article DOI: 10.1016/j.bmc.2008.09.058
BindingDB Entry DOI: 10.7270/Q2XP737X
More data for this
Ligand-Target Pair