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BDBM315214 2-(3-{[2-cyclopentyl-2-{4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetyl]amino}-2-methylphenyl)cyclopropanecarboxylic acid::US10172814, Example 156

SMILES: Cc1c(NC(=O)C(C2CCCC2)c2ccc(cc2)-c2cncc(c2)C(F)(F)F)cccc1C1CC1C(O)=O

InChI Key: InChIKey=PIGMVYYJRQEYNJ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 315214   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E synthase/G/H synthase 2


(Homo sapiens (Human))
BDBM315214
PNG
(2-(3-{[2-cyclopentyl-2-{4-[5-(trifluoromethyl)pyri...)
Show SMILES Cc1c(NC(=O)C(C2CCCC2)c2ccc(cc2)-c2cncc(c2)C(F)(F)F)cccc1C1CC1C(O)=O
Show InChI InChI=1S/C30H29F3N2O3/c1-17-23(24-14-25(24)29(37)38)7-4-8-26(17)35-28(36)27(19-5-2-3-6-19)20-11-9-18(10-12-20)21-13-22(16-34-15-21)30(31,32)33/h4,7-13,15-16,19,24-25,27H,2-3,5-6,14H2,1H3,(H,35,36)(H,37,38)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 32.9n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...


US Patent US10172814 (2019)


BindingDB Entry DOI: 10.7270/Q20K2BNW
More data for this
Ligand-Target Pair