BDBM315384 US10172856, Example 36

SMILES: Cc1cc(ccc1N(Cc1ncco1)c1ccnc(N)n1)S(F)(F)(F)(F)F

InChI Key: InChIKey=UMTJZNBNTDBOOM-UHFFFAOYSA-N

Data: 1 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 315384   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM315384 (US10172856, Example 36) Show SMILES Cc1cc(ccc1N(Cc1ncco1)c1ccnc(N)n1)S(F)(F)(F)(F)F Show InChI InChI=1S/C15H14F5N5OS/c1-10-8-11(27(16,17,18,19)20)2-3-12(10)25(9-14-22-6-7-26-14)13-4-5-23-15(21)24-13/h2-8H,9H2,1H3,(H2,21,23,24)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
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