BDBM315520 US10172858, Table 2.16::US9828378, # 16

SMILES CC(C)n1nc(-c2cc3cc(O)cc(F)c3[nH]2)c2c(N)ncnc12

InChI Key InChIKey=LUKIMGGLSGHDAN-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 315520   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Intellikine

US Patent
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50: <5nMAssay Description:This assay is relatively simple, reasonably sensitive, and the peptide substrate can be adjusted both in terms of sequence and concentration to meet ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50: <5nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Homo sapiens (Human))
Intellikine

US Patent
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50: >500nMAssay Description:This assay is relatively simple, reasonably sensitive, and the peptide substrate can be adjusted both in terms of sequence and concentration to meet ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50: <500nMAssay Description:This assay is relatively simple, reasonably sensitive, and the peptide substrate can be adjusted both in terms of sequence and concentration to meet ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50: <100nMAssay Description:This assay is relatively simple, reasonably sensitive, and the peptide substrate can be adjusted both in terms of sequence and concentration to meet ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytosolic arginine sensor for mTORC1 subunit 1(Homo sapiens (Human))
Intellikine

US Patent
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50: <5nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50: >500nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50: >500nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50: <500nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50: <100nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50: >500nMAssay Description:Inhibition of human PI3Kalpha preincubated for 15 mins followed by ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50: >500nMAssay Description:Inhibition of human PI3Kbeta preincubated for 15 mins followed by ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50:  100nMAssay Description:Inhibition of human PI3Kgamma preincubated for 15 mins followed by ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50:  50nMAssay Description:Inhibition of human PI3Kdelta preincubated for 15 mins followed by ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Intellikine

US Patent
LigandPNGBDBM315520(US10172858, Table 2.16 | US9828378, # 16)
Affinity DataIC50: >500nMAssay Description:This assay is relatively simple, reasonably sensitive, and the peptide substrate can be adjusted both in terms of sequence and concentration to meet ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent