BDBM315715 (S)-[2-Chloro-4- fluoro-5-(7- morpholin-4-yl- quinazolin-4-yl)- phenyl]-(6- methoxy- pyridazin-3-yl)- methanol1H NMR (500 MHz, DMSO-d6) ppm = 9.12 (s,1H), 7.91 (d, J = 7.7, 1H), 7.69 (d, J = 9.2, 1H),7.66 (d, J = 9.5, 1H), 7.61-7.52 (m, 2H), 7.24-7.19 (m, 2H), 6.61 (d, J = 5.0, 1H), 6.23 (d,J = 4.9, 1H), 4.00 (s, 3H), 3.81-3.75 (m, 4H),3.48-3.43 (m, 4H)::US10172859, Example 136::US11065253, Example 136::US9732094, Example 136

SMILES: COc1ccc(nn1)[C@@H](O)c1cc(c(F)cc1Cl)-c1ncnc2cc(ccc12)N1CCOCC1

InChI Key: InChIKey=MOWXJLUYGFNTAL-UHFFFAOYSA-N

Data: 2 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 315715   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA-dependent protein kinase catalytic subunit (Human)	BDBM315715 (US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
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DNA-dependent protein kinase catalytic subunit (Human)	BDBM315715 (US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
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DNA-dependent protein kinase catalytic subunit (Human)	BDBM315715 (US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
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DNA-dependent protein kinase catalytic subunit (Human)	BDBM315715 (US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
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DNA-dependent protein kinase catalytic subunit (Human)	BDBM315715 (US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM315715 (US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase mTOR (Human)	BDBM315715 (US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Human)	BDBM315715 (US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Human)	BDBM315715 (US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM315715 (US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM315715 (US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM315715 (US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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