BindingDB PrimarySearch

BDBM3175 3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione Methanesulfonate::BIM-9::Bisindolylmaleimide 11b::Bisindolylmaleimide IX::CHEMBL6291::ROCHE screening, 57::Ro 31-8220::Ro31-8220::[(3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl)sulfanyl]methanimidamide

SMILES: [H]/N=C(/N)\SCCCn1cc(c2c1cccc2)C3=C(C(=O)NC3=O)c4cn(c5c4cccc5)C

InChI Key: InChIKey=DSXXEELGXBCYNQ-UHFFFAOYSA-N

Data: 36 IC50 1 Kd 1 ITC

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 3175
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
NAD-dependent protein deacetylase sirtuin-2 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	206	n/a	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-1 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C alpha type (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-5 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase beta-1 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-3 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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NAD-dependent protein deacetylase sirtuin-1 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 12 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	143	n/a	n/a	n/a	n/a	n/a	n/a
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NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C alpha type (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
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Malate dehydrogenase (Thermus thermophilus)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Chymotrypsinogen B (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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NAD-dependent protein deacetylase sirtuin-1 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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NAD-dependent protein deacetylase HST2 (Baker's yeast)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase pim-1 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 1 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	52.9	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-dependent protein kinase catalytic subunit alpha (Bovine)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase pim-1 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	7.6	30
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Serine/threonine-protein kinase TBK1 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	656	n/a	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-3 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	25
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Glycogen synthase kinase-3 beta (Rat)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 8 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase VRK1 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	743	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase VRK2 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C beta type (Rat)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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Homeodomain-interacting protein kinase 1 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	621	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 10 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	n/a
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NAD-dependent protein deacetylase sirtuin-2 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
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NAD-dependent protein deacetylase sirtuin-2 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
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NAD-dependent protein deacetylase sirtuin-1 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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NAD-dependent protein deacetylase sirtuin-1 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
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NAD-dependent protein deacetylase sirtuin-1 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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NAD-dependent protein deacetylase sirtuin-2 (Human)	BDBM3175 (Bisindolylmaleimide 11b \| Ro 31-8220 \| CHEMBL6291 ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
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