BDBM31768 CHEMBL295698::Ketoconazole::Nizoral::Panfungol
SMILES CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1
InChI Key InChIKey=XMAYWYJOQHXEEK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 154 hits for monomerid = 31768
Affinity DataKi: 25nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomesMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of C17,20-lyase enzyme, cytochrome P450 17A1 in Human testicular microsomesMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of CYP3A4M in human liver microsomes using midazolam as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Human)
Cardiff University
Curated by ChEMBL
Cardiff University
Curated by ChEMBL
Affinity DataKi: 33nMAssay Description:Inhibition of human MBP-tagged CYP24A1 expressed in Escherichia coli using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reduc...More data for this Ligand-Target Pair
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Human)
Cardiff University
Curated by ChEMBL
Cardiff University
Curated by ChEMBL
Affinity DataKi: 35nMAssay Description:Inhibition of N-terminally MBP-fused human CYP24A1 by cell-free assayMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Binding affinity for Cytochrome P450 17A1 (17-alpha-hydroxypregnenolone Km=560 nM)More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of lanosterol 14 alpha-demethylase cytochrome P450 51AMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
Target25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Mouse)
Cardiff University
Curated by ChEMBL
Cardiff University
Curated by ChEMBL
Affinity DataKi: 58nMAssay Description:Inhibition of mouse CYP27B1 using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reductase and NADPH incubated at 37 degC for 2...More data for this Ligand-Target Pair
Target25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Mouse)
Cardiff University
Curated by ChEMBL
Cardiff University
Curated by ChEMBL
Affinity DataKi: 58nMAssay Description:Inhibition of mouse CYP27B1 by cell-free assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human placental microsome CYP19More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of CYP3A4 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of CYP3A4 in human liver microsomeMore data for this Ligand-Target Pair
Affinity DataKi: 64nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomesMore data for this Ligand-Target Pair
Affinity DataKi: 65nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase of rat hepatic microsomesMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Tested for inhibition of human testicular Steroid 17-alpha-hydroxylase/17,20 lyaseMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Tested for inhibition of human testicular Steroid 17-alpha-hydroxylase/17,20 lyaseMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of 17-alpha-hydroxylase enzyme, cytochrome P450 17A1 of human testicular microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZ cells using [3H] 11 deoxycorticosterone as substrate by HPLC radioflow detectorMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrateMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of human testicular microsomal Cytochrome P450 17A1More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of human testicular microsomal Cytochrome P450 17A1More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Cancer Research Campaign Centre For Cancer Therapeutics
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Binding affinity to human His-tagged CYP51 expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Binding affinity to human CYP51More data for this Ligand-Target Pair
Affinity DataIC50: 116nMAssay Description:Inhibition of recombinant CYP11B1 (unknown origin) overexpressed in human AD293 cells assessed as reduction in cortisol formation preincubated for 60...More data for this Ligand-Target Pair
Affinity DataIC50: 119nMAssay Description:Inhibition of lanosterol 14 alpha-demethylase cytochrome P450 51AMore data for this Ligand-Target Pair
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Human)
Cardiff University
Curated by ChEMBL
Cardiff University
Curated by ChEMBL
Affinity DataIC50: 126nMAssay Description:Inhibition of CYP24A1 in human epidermal keratinocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 127nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZ cells using [3H] 11 deoxycorticosterone as substrate by HPLC radioflow detectorMore data for this Ligand-Target Pair
Affinity DataIC50: 127nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 127nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant CYP3A4 assessed as conversion of luciferin-PPXE to D-luciferin by luminescence Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant CYP3A4 assessed as effect on conversion of beetle D-luciferin derivative into D-luciferin by firefly luciferase based...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant CYP3A4 assessed as remaining enzyme activity by measuring conversion of luciferin-PPXE into D-luciferin by luminescen...More data for this Ligand-Target Pair
Affinity DataIC50: 146nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 152nMAssay Description:Inhibition of Corticoid 11-beta-hydroxylase cytochrome P450More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 195nMAssay Description:Inhibition of cytochrome P450 Cholesterol 7-alpha-hydroxylaseMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant CYP3A4 expressed in insect cell microsomes preincubated for 10 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rat)
University of The West of Scotland
Curated by ChEMBL
University of The West of Scotland
Curated by ChEMBL
Affinity DataIC50: 206nMAssay Description:Inhibition of 17,20-lyase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rat)
University of The West of Scotland
Curated by ChEMBL
University of The West of Scotland
Curated by ChEMBL
Affinity DataIC50: 209nMAssay Description:Inhibition of rat Cytochrome P450 17A1More data for this Ligand-Target Pair
Affinity DataKd: 221nMAssay Description:Dissociation constant was determined in vitro using rat pituitary membranes and [125I]-leuprolide as radioligand, at concentration 3.16*10e-6 MMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) using 7-benzyloxy-4-trifluoromethylcoumarin as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Human)
Cardiff University
Curated by ChEMBL
Cardiff University
Curated by ChEMBL
Affinity DataIC50: 312nMAssay Description:Inhibition of human CYP24A1 expressed in chinese hamster V79 cellsMore data for this Ligand-Target Pair
