BDBM318726 7-(3,5-dimethylisoxazol-4-yl)-9-(3,5- dimethyl-1H-pyrazol-4-yl)-4-pyridin-2-yl- 4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazin-2(1H)-one::US10464947, Example 258::US11498926, Example 258::US9624241, Example 258

SMILES Cc1n[nH]c(C)c1-c1cc(-c2c(C)noc2C)c2OCC(c3ccccn3)n3c2c1[nH]c3=O

InChI Key InChIKey=ZQVZUVFWGLQHPH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 318726   

TargetBromodomain-containing protein 4 [353-454](Human)
Incyte

US Patent
LigandPNGBDBM318726(US9624241, Example 258 | 7-(3,5-dimethylisoxazol-4...)
Affinity DataIC50: 550nMAssay Description:Table 12: BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2023
Entry Details
US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte Holdings

US Patent
LigandPNGBDBM318726(US9624241, Example 258 | 7-(3,5-dimethylisoxazol-4...)
Affinity DataIC50: 550nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte Holdings

US Patent
LigandPNGBDBM318726(US9624241, Example 258 | 7-(3,5-dimethylisoxazol-4...)
Affinity DataIC50: 550nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [58-164](Human)
Incyte

US Patent
LigandPNGBDBM318726(US9624241, Example 258 | 7-(3,5-dimethylisoxazol-4...)
Affinity DataIC50: 5.50E+3nMAssay Description:Table 11: BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2023
Entry Details
US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
Incyte

US Patent
LigandPNGBDBM318726(US9624241, Example 258 | 7-(3,5-dimethylisoxazol-4...)
Affinity DataIC50: 5.50E+3nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Incyte Holdings

US Patent
LigandPNGBDBM318726(US9624241, Example 258 | 7-(3,5-dimethylisoxazol-4...)
Affinity DataIC50: 5.50E+3nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2020
Entry Details
US Patent