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BDBM318986 N-[(cyclopropyl- carbamoyl) methyl]-2-(2- methoxy- ethanesulfonyl)- 2-{6-[4-(N- methylacetamido) phenyl]-1,3- benzothiazol-2- yl}acetamide::US10173991, Example 27

SMILES: CN(C(C)=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCCO

InChI Key: InChIKey=KGUHCDVQDMUNCS-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 318986   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endothelial lipase


(Homo sapiens (Human))
BDBM318986
PNG
(N-[(cyclopropyl- carbamoyl) methyl]-2-(2- methoxy-...)
Show SMILES CN(C(C)=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCCO
Show InChI InChI=1S/C26H30N4O6S2/c1-16(32)30(2)20-9-4-17(5-10-20)18-6-11-21-22(14-18)37-26(29-21)24(38(35,36)13-3-12-31)25(34)27-15-23(33)28-19-7-8-19/h4-6,9-11,14,19,24,31H,3,7-8,12-13,15H2,1-2H3,(H,27,34)(H,28,33)
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PC cid
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US Patent
n/an/a 58n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)


BindingDB Entry DOI: 10.7270/Q2N018M8
More data for this
Ligand-Target Pair