BindingDB PrimarySearch

BDBM31915 CDV::Cidofovir::HPMPC::US10071110, Compound Cidofovir::Vistide

SMILES: Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1

InChI Key: InChIKey=VWFCHDSQECPREK-LURJTMIESA-N

Data: 6 IC50 1 Kd 1 EC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 31915
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (IspF) (Escherichia coli (strain K12))	BDBM31915 (CDV \| Cidofovir \| HPMPC \| US10071110, Compound Cid...) Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEBI DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	4.00E+7	n/a	n/a	n/a	7.0	10
University of Dundee					Assay Description An SPR assay was used to determine the binding affinities of compounds. Experiments were performed on a Biacore 3000 (Biacore, Uppsala, Sweden) instr...				J Med Chem 52: 2531-42 (2009) Article DOI: 10.1021/jm801475n BindingDB Entry DOI: 10.7270/Q23B5XGB
University of Dundee					More data for this Ligand-Target Pair
Thymidine kinase (Macacine herpesvirus 1)	BDBM31915 (CDV \| Cidofovir \| HPMPC \| US10071110, Compound Cid...) Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1 Show InChI	UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	9.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
GLSynthesis Inc. Curated by ChEMBL					Assay Description Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation				Antimicrob Agents Chemother 51: 2028-34 (2007) Article DOI: 10.1128/AAC.01284-06 BindingDB Entry DOI: 10.7270/Q2RN38R9
GLSynthesis Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
HIV-1 protease (Human immunodeficiency virus)	BDBM31915 (CDV \| Cidofovir \| HPMPC \| US10071110, Compound Cid...) Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1 Show InChI	PDB MMDB UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
The Regents of the University of California US Patent					Assay Description Subconfluent MRC-5 cells in 24-well culture dishes were inoculated by removing the medium and adding HSV-1 virus at a dilution that will result in a ...				US Patent US10071110 (2018) BindingDB Entry DOI: 10.7270/Q2NS0WX9
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Solute carrier family 22 member 6 (Homo sapiens (Human))	BDBM31915 (CDV \| Cidofovir \| HPMPC \| US10071110, Compound Cid...) Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells				Anal Biochem 283: 49-55 (2000) Article DOI: 10.1006/abio.2000.4633 BindingDB Entry DOI: 10.7270/Q2DR2ZC6
Gilead Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 1 (Homo sapiens (Human))	BDBM31915 (CDV \| Cidofovir \| HPMPC \| US10071110, Compound Cid...) Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1 Show InChI	Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM31915 (CDV \| Cidofovir \| HPMPC \| US10071110, Compound Cid...) Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Multidrug resistance-associated protein 4 (Homo sapiens (Human))	BDBM31915 (CDV \| Cidofovir \| HPMPC \| US10071110, Compound Cid...) Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 2 (Homo sapiens (Human))	BDBM31915 (CDV \| Cidofovir \| HPMPC \| US10071110, Compound Cid...) Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair