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BDBM319254 N-[(cyclopropyl- carbamoyl) methyl]-2-(2- methoxyethane- sulfonyl)-2-{6-[6- (pyaolidin-1- yl)pyridin-3-yl]- 1,3-benzothiazol- 2-yl}acetamide::US10173991, Example 298

SMILES: COCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2ccc(cc2s1)-c1ccc(nc1)N1CCCC1

InChI Key: InChIKey=KQHSBHISCHKOMR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319254   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endothelial lipase


(Homo sapiens (Human))
BDBM319254
PNG
(N-[(cyclopropyl- carbamoyl) methyl]-2-(2- methoxye...)
Show SMILES COCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2ccc(cc2s1)-c1ccc(nc1)N1CCCC1
Show InChI InChI=1S/C26H31N5O5S2/c1-36-12-13-38(34,35)24(25(33)28-16-23(32)29-19-6-7-19)26-30-20-8-4-17(14-21(20)37-26)18-5-9-22(27-15-18)31-10-2-3-11-31/h4-5,8-9,14-15,19,24H,2-3,6-7,10-13,16H2,1H3,(H,28,33)(H,29,32)
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US Patent
n/an/a 118n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)


BindingDB Entry DOI: 10.7270/Q2N018M8
More data for this
Ligand-Target Pair