BDBM320632 3-(Fluoromethyl)-6-hydroxy-1-(2-methyl-1- (4-(trifluoromethyl)phenyl)propyl)-1H- pyrazolo[3,4-d]pyrimidin-4(5H)-one::US10174037, Example 40

SMILES CC(C)C(c1ccc(cc1)C(F)(F)F)n1nc(CF)c2c1nc(O)[nH]c2=O

InChI Key InChIKey=MXLZZLVJZJXPRN-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 320632   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320632(3-(Fluoromethyl)-6-hydroxy-1-(2-methyl-1- (4-(trif...)
Affinity DataKi:  0.560nMAssay Description:Performed by Lab A. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320632(3-(Fluoromethyl)-6-hydroxy-1-(2-methyl-1- (4-(trif...)
Affinity DataKi:  1.70nMAssay Description:Performed by Lab A. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320632(3-(Fluoromethyl)-6-hydroxy-1-(2-methyl-1- (4-(trif...)
Affinity DataKi:  2nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320632(3-(Fluoromethyl)-6-hydroxy-1-(2-methyl-1- (4-(trif...)
Affinity DataKi:  2.10nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent