BDBM320670 (R)- or (S)-6-(Dimethylamino)-3- (hydroxymethyl)-1-(1-(4- isopropylphenyl)-2-methylpropyl)- 1H-pyrazolo[3,4-d]pyrimidin-4(5H)- one::US10174037, Example 78::US10174037, Example 79

SMILES CC(C)C(c1ccc(cc1)C(C)C)n1nc(CO)c2c1nc([nH]c2=O)N(C)C

InChI Key

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 320670   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320670((R)- or (S)-6-(Dimethylamino)-3- (hydroxymethyl)-1...)
Affinity DataKi:  0.0440nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320670((R)- or (S)-6-(Dimethylamino)-3- (hydroxymethyl)-1...)
Affinity DataKi:  0.0540nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320670((R)- or (S)-6-(Dimethylamino)-3- (hydroxymethyl)-1...)
Affinity DataKi:  0.110nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320670((R)- or (S)-6-(Dimethylamino)-3- (hydroxymethyl)-1...)
Affinity DataKi:  0.140nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent